重症哮喘患者对生物制剂家庭给药的看法：一项国际定性研究
2022/05/17
摘要
背景：生物制剂是治疗重症哮喘的有效方法。患者在家中使用生物制剂可能更便利。然而，患者和医务人员（HCP）对生物制剂的家庭管理知之甚少。
目的：本研究的目的是让人们更深入地了解患者和医务人员在治疗重症哮喘的背景下，对生物制剂家庭给药的看法和经验。
方法：在荷兰、美国、澳大利亚和英国进行定性国际研究。在每个国家，都与国内潜在/近期和长期生物制剂使用者建立了两个焦点小组。在焦点小组之前，患者会在在线论坛上得到主题提示。为了进行三角定位，与医务人员进行了访谈，讨论论坛和焦点小组的重要发现。数据分析采用定性内容分析。
结果：共有75名患者参加了论坛，其中40人参加了焦点小组。此外，还采访了12名医务人员。确定了以下主要主题：患有重症哮喘；使用生物制剂的实践方面；HCP在生物制品方面的作用；来自家人、朋友和其他人的社会支持；生物制剂和其他治疗的有效性；生物制剂的副作用。
结论：本研究表明，对于那些使用生物制剂治疗重症哮喘患者，家庭使用生物制剂的益处通常大于不便和副作用。在从医院到家庭哮喘生物制剂管理的过渡过程中，指导性实践、可获得的接触支持以及包括社会支持在内的监测应该是核心。
Perceptions on home-administration of biologics in the context of severe asthma: an international qualitative study
Bertine Flokstra-de Blok, Janwillem Kocks, Hans Wouters, Chantal Arling, Josh Chatelier, Jo Douglass, Liam G Heaney, Joshua Holmes, Marc Humbert, Mary Kolanowski, Jeanet Ja Landsman, Njira Lugogo, Alice Malpass, Jiska Meijer, Boyd Metz, Bibicha de Mu, Frank Postma, Marika Leving
Abstract
Background: Biologics are an effective therapy for severe asthma. Home-administration of biologics by patients is likely to facilitate their accessibility. Yet, little is known about patients' and health care providers' (HCPs) perceptions regarding home-administration of biologics.
Objective: The aim of this study is to create more insight into the perceptions and experiences of patients and HCPs regarding home-administration of biologics in the context of the treatment of severe asthma.
Methods: A qualitative international study was performed in the Netherlands, United States, Australia, and United Kingdom. In each country, two focus groups were held with potential/recent and long-term users of biologics at home. Prior to the focus groups, patients were prompted with themes on online forums. For triangulation purposes, interviews were held with HCPs to discuss salient findings from forums and focus groups. Data were analyzed with qualitative content analysis.
Results: In total, 75 patients participated in the forums, of which 40 participated in the focus groups. Furthermore, 12 HCPs were interviewed. The following overarching themes were identified: living with severe asthma; practical aspects of using biologics; the role of HCPs regarding biologics; social support from family, friends, and others; effectiveness of biologics and other treatments; side-effects of biologics.
Conclusion: This study showed that for those using biologics for severe asthma, the benefits of home-administration of biologics usually outweigh inconvenience and side-effects. Guided practice, accessible support contact, and monitoring including social support, should be central in the transition from hospital to home-administration of asthma biologics.
背景：生物制剂是治疗重症哮喘的有效方法。患者在家中使用生物制剂可能更便利。然而，患者和医务人员（HCP）对生物制剂的家庭管理知之甚少。
目的：本研究的目的是让人们更深入地了解患者和医务人员在治疗重症哮喘的背景下，对生物制剂家庭给药的看法和经验。
方法：在荷兰、美国、澳大利亚和英国进行定性国际研究。在每个国家，都与国内潜在/近期和长期生物制剂使用者建立了两个焦点小组。在焦点小组之前，患者会在在线论坛上得到主题提示。为了进行三角定位，与医务人员进行了访谈，讨论论坛和焦点小组的重要发现。数据分析采用定性内容分析。
结果：共有75名患者参加了论坛，其中40人参加了焦点小组。此外，还采访了12名医务人员。确定了以下主要主题：患有重症哮喘；使用生物制剂的实践方面；HCP在生物制品方面的作用；来自家人、朋友和其他人的社会支持；生物制剂和其他治疗的有效性；生物制剂的副作用。
结论：本研究表明，对于那些使用生物制剂治疗重症哮喘患者，家庭使用生物制剂的益处通常大于不便和副作用。在从医院到家庭哮喘生物制剂管理的过渡过程中，指导性实践、可获得的接触支持以及包括社会支持在内的监测应该是核心。
(中日友好医院呼吸与危重症医学科 李红雯 摘译 林江涛 审校)
(J Allergy Clin Immunol Pract. 2022 Apr 26;S2213-2198(22)00363-4. doi: 10.1016/j.jaip.2022.04.015.)
(J Allergy Clin Immunol Pract. 2022 Apr 26;S2213-2198(22)00363-4. doi: 10.1016/j.jaip.2022.04.015.)
Perceptions on home-administration of biologics in the context of severe asthma: an international qualitative study
Bertine Flokstra-de Blok, Janwillem Kocks, Hans Wouters, Chantal Arling, Josh Chatelier, Jo Douglass, Liam G Heaney, Joshua Holmes, Marc Humbert, Mary Kolanowski, Jeanet Ja Landsman, Njira Lugogo, Alice Malpass, Jiska Meijer, Boyd Metz, Bibicha de Mu, Frank Postma, Marika Leving
Abstract
Background: Biologics are an effective therapy for severe asthma. Home-administration of biologics by patients is likely to facilitate their accessibility. Yet, little is known about patients' and health care providers' (HCPs) perceptions regarding home-administration of biologics.
Objective: The aim of this study is to create more insight into the perceptions and experiences of patients and HCPs regarding home-administration of biologics in the context of the treatment of severe asthma.
Methods: A qualitative international study was performed in the Netherlands, United States, Australia, and United Kingdom. In each country, two focus groups were held with potential/recent and long-term users of biologics at home. Prior to the focus groups, patients were prompted with themes on online forums. For triangulation purposes, interviews were held with HCPs to discuss salient findings from forums and focus groups. Data were analyzed with qualitative content analysis.
Results: In total, 75 patients participated in the forums, of which 40 participated in the focus groups. Furthermore, 12 HCPs were interviewed. The following overarching themes were identified: living with severe asthma; practical aspects of using biologics; the role of HCPs regarding biologics; social support from family, friends, and others; effectiveness of biologics and other treatments; side-effects of biologics.
Conclusion: This study showed that for those using biologics for severe asthma, the benefits of home-administration of biologics usually outweigh inconvenience and side-effects. Guided practice, accessible support contact, and monitoring including social support, should be central in the transition from hospital to home-administration of asthma biologics.
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U-BIOPRED队列中持续恶化的严重哮喘的临床和转录组特征
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支气管活检中哮喘相关microRNA的鉴定
