吸入甘露醇激发试验在咳嗽评价中的应用
2009/11/17
在支气管激发试验中，可使用多种直接或间接吸入物激发气道反应，以评价气道高反应性。甘露醇是一种简单且易于使用的高渗性刺激物，已在许多国家使用，目前正接受美国FDA的审批。健康人群中气道对吸入性甘露醇无反应，而哮喘患者则产生类似于高渗盐水和运动诱导的支气管反应的气道狭窄反应。甘露醇同时具有诱发咳嗽的作用，该作用不依赖于支气管收缩，表明该作用与其诱导的支气管反应具有不同的生理学作用通路。慢性咳嗽患者对甘露醇的敏感性增加，甘露醇测试可用于特异性评价咳嗽反应。
（刘国梁 审校）
Spector S. Lung. 2009 Sep 16.
Use of Mannitol Inhalation Challenge in Assessment of cough.
Bronchial provocation testing uses a variety of direct and indirect inhalational challenges to evaluate airway hyperreactivity. Mannitol, a simple, easy-to-administer hypertonic stimulus available in many countries, is currently under review by the FDA in the US. Healthy subjects show no airway response to inhaled mannitol; asthmatic patients respond with airway narrowing similar to challenges with hypertonic saline and exercise. Mannitol challenge also has a tussive effect that is independent of bronchoconstriction, suggesting different physiologic pathways. Patients with chronic cough show increased sensitivity to mannitol, and mannitol testing may be useful for evaluating heterogeneity in the cough response.
Spector S. Lung. 2009 Sep 16.
（刘国梁 审校）
Spector S. Lung. 2009 Sep 16.
Use of Mannitol Inhalation Challenge in Assessment of cough.
Bronchial provocation testing uses a variety of direct and indirect inhalational challenges to evaluate airway hyperreactivity. Mannitol, a simple, easy-to-administer hypertonic stimulus available in many countries, is currently under review by the FDA in the US. Healthy subjects show no airway response to inhaled mannitol; asthmatic patients respond with airway narrowing similar to challenges with hypertonic saline and exercise. Mannitol challenge also has a tussive effect that is independent of bronchoconstriction, suggesting different physiologic pathways. Patients with chronic cough show increased sensitivity to mannitol, and mannitol testing may be useful for evaluating heterogeneity in the cough response.
Spector S. Lung. 2009 Sep 16.
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前列腺素E2通过EP3受体调节咳嗽：对未来咳嗽治疗的意义
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COPD患者对吸入辣椒素诱导的咳嗽敏感性与急性加重频率增加相关
