哮喘联盟

   摘要
   蠕虫寄生生物长期寄生于其哺乳动物宿主中，从而建立了一个非常特别的免疫微环境来支持该病原体和宿主的健康。当今发达社会的现代生活方式几乎完全消除了人类身上的寄生生物，因此打破了这个紧密的联系。有人认为，作为这个进程的结果，哮喘和其他炎症性疾病的发生率也会快速增加。实验模型的数据清楚的显示了蠕虫及其产物能改善小鼠的哮喘类疾病。本综述着重于寄生虫驱动的调节机制对于实验性哮喘的嗜酸细胞和中性粒细胞功能的影响。嗜酸细胞和中性粒细胞是引起肺部病理学改变重要效应细胞，因此了解如何控制其在哮喘急性发作中的活化作用，可能有助于研发更多必要的新治疗方法来对抗这种常见的炎症性疾病。
 

（林江涛 审校）
Curr Mol Med. 2013 Jun 28. [Epub ahead of print]

 

Impact of worms and their products on eosinophils and neutrophils in experimental asthma.
 

Rzepecka J, Harnett W.
 

Abstract
Prolonged existence of helminth parasites in their mammalian hosts has led to the establishment of a very particular immunological microenvironment that supports the fitness of both the pathogen and the host. The modern way of living in developed societies has interrupted this tight relationship by virtually completely removing helminths from the human population. It is believed that, as a consequence of this process, a rapid increase in the incidence of asthma and other inflammatory disorders has occurred. Data derived from experimental models clearly show that worms and their products can ameliorate asthma-like disease in mice. This review will concentrate on the effects of helminth-driven regulatory mechanisms on the function of eosinophils and neutrophils in experimental asthma. Eosinophils and neutrophils are major effector cells driving pathology in the lung, therefore learning how to control their exacerbated activation in asthma might aid in creating much needed novel therapeutics to combat this common inflammatory disorder.
 

Curr Mol Med. 2013 Jun 28. [Epub ahead of print]