哮喘联盟

   摘要
   目的：本研究目的旨在评估哮喘患儿在哮喘急性发作期间的尿白三烯E4 （ULTE4 ）水平，及其与总血清(TS)免疫球蛋白(Ig) E水平（TS IgE与哮喘严重程度相关）的相关性。
   方法：本前瞻性研究从2011年11月至2012年5月在埃及本哈的本哈大学医院儿科急诊室进行。本研究纳入63例哮喘急性发作儿童（I组）和25例健康儿童作为对照（Ⅱ组），其年龄范围在3～14岁间。对所有儿童进行完整病史采集，并着重于哮喘急性发作症状和完整的临床检查。在经受试儿童父母同意后，通过酶联免疫吸附法测定受试儿童的TS IgE与 ULTE4。取患儿入院时的尿液样本测定ULTE4浓度，并通过尿肌酐浓度校正LTE4浓度。
   结果：病例组ULTE4水平显著高于对照组(309.7±97.1 vs 14.5±5.7 pg/mg 肌酐)，并与TS IgE和哮喘严重程度均呈正相关。另外，与对照组相比(45.5±22.1 IU/mL)，病例组TS IgE水平(392.1±309.7 IU/mL)显著增加。
   结论：儿童急性哮喘发作期间ULTE4和TS IgE水平显著增加。哮喘发作的严重程度与ULTE4水平呈显著正相关性，预示其可成为监测哮喘患儿急性哮喘发作以及后续炎症进程的良好的无创性标志物。
 

（苏楠 审校）
Int J Gen Med. 2014 Mar 3;7:131-5. doi: 10.2147/IJGM.S56660. eCollection 2014.

 

Study of urinary leukotriene E4 levels in children with acute asthma.
 

Abd El-Motaleb GS1, Abou Amer AA1, Elawa GM2, Abo Alsood Abd Elfattah M3.
 

Abstract
OBJECTIVE: The goal of this study was to evaluate the impact of urinary leukotriene E4 (ULTE4) in asthmatic children during acute asthma exacerbation. Also, we wanted to correlate it with the total serum (TS) immunoglobulin (Ig) E level in relation to asthma severity.
METHODS: This prospective study was conducted in the emergency room of the Department of Pediatrics, Benha University Hospital in Benha, Egypt, from November 2011 to May 2012. In this study, 63 children with acute asthma exacerbation (group I) and 25 healthy children as the control (group II) were included. Their ages ranged between 3-14 years. All children were subjected to a full medical history, and an emphasis was placed on the symptoms of asthma exacerbation and a complete clinical examination. TS IgE and ULTE4 were measured by an enzyme-linked immunosorbent assay after receiving the parents' consent. The LTE4 concentration was measured in urine samples obtained at the onset of admission and adjusted by urinary creatinine concentrations.
RESULTS: The ULTE4 levels were significantly higher in cases compared to the controls (309.7±97.1 versus 14.5±5.7 pg/mg creatinine, respectively). It correlated positively to both the TS IgE and asthma severity in the cases. Also, the TS IgE levels increased significantly in cases (392.1±309.7 IU/mL), when compared to the controls (45.5±22.1 IU/mL).
CONCLUSION: The ULTE4 and the TS IgE levels are significantly elevated during acute asthma episodes in children. The significant positive correlation between the severity of these attacks and the ULTE4 levels makes it a good noninvasive marker for monitoring acute asthma exacerbations and follow-up of the inflammatory process in asthmatic children.
 

Int J Gen Med. 2014 Mar 3;7:131-5. doi: 10.2147/IJGM.S56660. eCollection 2014.