气道上皮屏障功能调节过敏性哮喘的发病机制
2014/05/08
摘要
哮喘患者气道上皮完整性和上皮细胞间的连接往往已被破坏。气道上皮细胞功能障碍可能对哮喘造成重要的影响，因为在结构上上皮细胞屏障功能与上皮调节免疫系统的能力紧密地交织在一起。我们提出，气道上皮屏障改变在对过敏原的敏感性和过敏性哮喘的发病机制中占有核心作用。最近发现许多哮喘易感基因在气道上皮细胞中表达。哮喘患者上皮易感基因转录表达使其功能改变对空气致敏原反应的确切机制尚不清楚。本文论述主要关注气道上皮屏障功能在发展为过敏性哮喘易感中的作用，并讨论了基于气道屏障的治疗策略。
（林江涛 审校）
Clin Exp Allergy. 2014 Feb 25. doi: 10.1111/cea.12296. [Epub ahead of print]
Airway epithelial barrier function regulates the pathogenesis of allergic asthma.
Heijink IH1, Nawijn MC, Hackett TL.
ABSTRACT
The integrity of the airway epithelium in asthma patients is often disrupted, with loss of epithelial cell-cell contacts. Airway epithelial barrier dysfunction may have important implications for asthma, since structural epithelial barrier function is tightly interwoven with the ability of the epithelium to regulate the immune system. We propose that changes at the airway epithelial barrier play a central role in the sensitization to allergens and pathogenesis of allergic asthma. Many of the recently identified susceptibility genes for asthma are expressed in airway epithelium. However, the exact mechanisms by which the expression of epithelial susceptibility genes translate into a functionally altered response to aeroallergens in asthma is still unknown. In this review we will focus on the role of airway epithelial barrier function in the susceptibility to develop allergic asthma, and discuss therapeutic strategies aimed at the epithelial barrier. This article is protected by copyright. All rights reserved.
Clin Exp Allergy. 2014 Feb 25. doi: 10.1111/cea.12296. [Epub ahead of print]
