月经前哮喘发生率的变化
2010/02/23
该研究旨在根据一定标准，分析月经前哮喘发生率的差异，及其对哮喘严重程度的影响。对“月经前哮喘是否加重？”做肯定回答者被认为是主观经前期哮喘。
在连续两个月经周期以日记的方式记录育龄哮喘女性的呼吸道症状。对于半客观诊断，症状记录中必须有峰值流量恶化≥20％。以月经前峰值流量恶化≥20％作为客观诊断。
共纳入103例患者。43.7％的患者存在主观经前期哮喘恶化。在第一个月经周期内和第二个月经周期内症状半客观诊断恶化的患者分别占44.7％和22.3％。54.3％伴第一个月经周期内有半客观诊断恶化的女性有主观恶化症状，相比之下，仅35.1％第一个月经周期内无半客观诊断恶化的女性有主观恶化症状（P=0.05）。
月经前哮喘（PMA）存在于不同哮喘严重程度的患者中，与哮喘严重程度关系尚不清楚。PMA发生率的检测、患者主观哮喘恶化感知和PMA存在于各严重程度哮喘的患者中，这些敦促我们应在所有育龄哮喘女性中对月经前哮喘恶化的可能性进行研究。
（苏楠 审校）
Eur Respir J. 2009 Nov 6. [Epub ahead of print]
Variability in the prevalence of premenstrual asthma.
Pereira Vega A, Ramos JL, Pérez JA, Gutierrez FJ, García JM, Oliva RV, Palacios PR, Nieto JM, Rodríguez IS, Muñoz YF.
Our aim is to analyse the differences in the prevalence of premenstrual asthma according to a set of criteria, the relationship between them and the influence of asthma severity.The answer Yes to Does your asthma get worse during the premenstrual phase? was considered subjective premenstrual asthma. A daily respiratory symptoms register of fertile asthmatic females was taken during two consecutive menstrual cycles. For the semi-objective diagnosis, an exacerbation of >/=20% was required in the symptoms register. Objective diagnosis was a premenstrual worsening of >/=20% of peak flow.We selected 103 patients. Subjective premenstrual deterioration was perceived in 43.7%. The semi-objective deterioration of symptoms in the first cycle occurred in 44.7%, and in 22.3% in both cycles. A total of 54.3% of females with semi-objective criteria in the first cycle perceived a subjective deterioration of symptoms, versus 35.1% of those without semi-objective criteria (p=0.05). Premenstrual Asthma (PMA) was present at all levels of asthma severity with no clear link to the degree of severity.The detection of PMA prevalence, the subjective perception of this deterioration and its presence at all levels of asthma severity leads us to urge research into possible premenstrual deterioration in all fertile asthmatic females.
Pereira Vega A, Ramos JL, Pérez JA, et al. Eur Respir J. 2009 Nov 6. [Epub ahead of print]
在连续两个月经周期以日记的方式记录育龄哮喘女性的呼吸道症状。对于半客观诊断，症状记录中必须有峰值流量恶化≥20％。以月经前峰值流量恶化≥20％作为客观诊断。
共纳入103例患者。43.7％的患者存在主观经前期哮喘恶化。在第一个月经周期内和第二个月经周期内症状半客观诊断恶化的患者分别占44.7％和22.3％。54.3％伴第一个月经周期内有半客观诊断恶化的女性有主观恶化症状，相比之下，仅35.1％第一个月经周期内无半客观诊断恶化的女性有主观恶化症状（P=0.05）。
月经前哮喘（PMA）存在于不同哮喘严重程度的患者中，与哮喘严重程度关系尚不清楚。PMA发生率的检测、患者主观哮喘恶化感知和PMA存在于各严重程度哮喘的患者中，这些敦促我们应在所有育龄哮喘女性中对月经前哮喘恶化的可能性进行研究。
（苏楠 审校）
Eur Respir J. 2009 Nov 6. [Epub ahead of print]
Variability in the prevalence of premenstrual asthma.
Pereira Vega A, Ramos JL, Pérez JA, Gutierrez FJ, García JM, Oliva RV, Palacios PR, Nieto JM, Rodríguez IS, Muñoz YF.
Our aim is to analyse the differences in the prevalence of premenstrual asthma according to a set of criteria, the relationship between them and the influence of asthma severity.The answer Yes to Does your asthma get worse during the premenstrual phase? was considered subjective premenstrual asthma. A daily respiratory symptoms register of fertile asthmatic females was taken during two consecutive menstrual cycles. For the semi-objective diagnosis, an exacerbation of >/=20% was required in the symptoms register. Objective diagnosis was a premenstrual worsening of >/=20% of peak flow.We selected 103 patients. Subjective premenstrual deterioration was perceived in 43.7%. The semi-objective deterioration of symptoms in the first cycle occurred in 44.7%, and in 22.3% in both cycles. A total of 54.3% of females with semi-objective criteria in the first cycle perceived a subjective deterioration of symptoms, versus 35.1% of those without semi-objective criteria (p=0.05). Premenstrual Asthma (PMA) was present at all levels of asthma severity with no clear link to the degree of severity.The detection of PMA prevalence, the subjective perception of this deterioration and its presence at all levels of asthma severity leads us to urge research into possible premenstrual deterioration in all fertile asthmatic females.
Pereira Vega A, Ramos JL, Pérez JA, et al. Eur Respir J. 2009 Nov 6. [Epub ahead of print]
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新西兰工作组调查II：哮喘的职业危险因素
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父母的职业是儿童喘息和哮喘的危险因素之一
