淋巴毒素-α基因+252A/G多态性增加哮喘风险：荟萃分析
2012/10/11
摘要
背景和目的：一些研究显示，淋巴毒素-α（LT-α）基因+252A/G多态性（rs909253）与哮喘易感性相关。然而，研究结果存在分歧。本试验采用荟萃分析，研究LT-α基因+252A/G多态性与哮喘风险的相关性。
方法：检索Pubmed和Embase数据库，选取有关LT-α基因+252A/G多态性与哮喘风险的研究。采用Revman4.2和STATA 10.0进行统计分析。
结果：13项病例-对照研究入选，共计有2220例病例，6428例对照。综合分析未见LT-α基因+252A/G多态性与哮喘风险存在相关（GG+GA vs. AA：OR: 1.14, 95% CI 0.89-1.45）。针对种族的亚组分析显示，亚洲人（OR 1.31, 95% CI 0.97-1.77）和欧洲人（OR 1.08, 95% CI 0.77-1.53）也未观察到上述相关性。针对年龄的亚组分析显示，成人（OR 1.25, 95% CI 1.03-1.50），而非儿童（OR 1.04, 95% CI 0.28-3.89），存在LT-α基因+252A/G多态性与哮喘风险相关。针对过敏状态的亚组分析显示，特应性患者存在相关性（OR 1.55, 95% CI 1.28-1.87），而非特应性患者无此相关性（OR 0.94, 95% CI 0.53-1.68）。
结论：荟萃分析显示，LT-α基因+252A/G多态性是成人和特应性人群哮喘的一个危险因素。
（刘国梁 审校）
Respirology. 2012 Aug 10.doi: 10.1111/j.1440-1843.2012.02243.x.[Epub ahead of print]
Respirology. 2012 Aug 10.doi: 10.1111/j.1440-1843.2012.02243.x.[Epub ahead of print]
Source
Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Department of Intensive Care Unit, The Second Hospital of Anhui Medical University, Hefei, Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, China.
Abstract
BACKGROUND AND OBJECTIVE:A number of studies have shown that the +252A/G polymorphism (rs909253) in the lymphotoxin-α (LT-α) gene is implicated in susceptibility to asthma. However, the findings have been inconclusive. The aim of this study was to investigate the association between the +252A/G polymorphism in the LT-α gene and the risk of asthma by performing a meta-analysis.
METHODS:The Pubmed and Embase databases were searched for all studies relating to this polymorphism and the risk of asthma. Statistical analyses were performed using the Revman4.2 and STATA 10.0 software.
RESULTS:Thirteen case-control studies that included a total of 2220 cases and 6428 controls were included in the meta-analysis. There was no significant association between this polymorphism and the risk of asthma in the all-combined analysis [odds ratio (OR) 1.14, 95% confidence interval (CI) 0.89-1.45 for GG+GA vs. AA]. In a subgroup analysis by ethnicity, no significant association with asthma risk was identified in Asians (OR 1.31, 95% CI 0.97-1.77) or Europeans (OR 1.08, 95% CI 0.77-1.53). In a subgroup analysis by age, a significantly increased risk was identified among adults (OR 1.25, 95% CI 1.03-1.50) but not children (OR 1.04, 95% CI 0.28-3.89). In a subgroup analysis by atopic status, a significantly elevated risk was identified among atopic (OR 1.55, 95% CI 1.28-1.87) but not non-atopic individuals (OR 0.94, 95% CI 0.53-1.68).
CONCLUSIONS:This meta-analysis suggested that the +252A/G polymorphism in the LT-α gene is a risk factor for asthma in adults and atopic populations.
Respirology. 2012 Aug 10.doi:10.1111/j.1440-1843.2012.02243.x.[Epub ahead of print]
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